Amifostine thiol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Amifostine thiol (WR-1065) 是细胞保护剂 Amifostine (HY-B0639) 的活性代谢物。Amifostine thiol 是一种具有辐射防护能力的细胞保护剂。Amifostine thiol 通过 JNK 依赖的信号通路激活 p53。

Amifostine thiol (WR-1065) is an active metabolite of the cytoprotector Amifostine (HY-B0639). Amifostine thiol is a cytoprotective agent with radioprotective abilities. Amifostine thiol activates p53 through a JNK-dependent signaling pathway.

Amifostine thiol can reduce both the direct and delayed detrimental effects of both high and low-LET radiation exposures.Amifostine thiol attenuates both the DNA damage and the G1-phase arrest induced by radiation. Amifostine thiol (4 mM; 30 minutes) protects RKO36 cells from chromosomal damage and death induced by ionizing radiation.Amifostine thiol (4 mM; 30 minutes) protects irradiated RKO36 cells from delayed genomic instability.Amifostine thiol is cytotoxic to RKO36 cells at milimolar concentrations, especially after continuous treatment.Amifostine thiol at 40 μM protects RKO36 cells from delayed genomic instability but not from cell death and immediate chromosomal damage.Amifostine thiol activates JNK resulting in the phosphorylation of p53 at threonine 81.Amifostine thiol affects phosphorylation of topoisomerase IIα leading to changes in enzyme activity and cell cycle progression in CHO AA8 cells.

——

——

Apoptosis

MDM2-p53

Mdm2 | p53

——

——

31098-42-7

134.24

C5H14N2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (1862.34 mM; 超声助溶 ) H2O 中的溶解度 : 100 mg/mL (744.93 mM; 超声助溶)

NCCCNCCS

——

(-20℃)

With Ice Pack

≥ 2 years